Skip to main content
Log in

Study of the conformational states of amino-alcohol derivatives of some alkaloids and bases and their protonated forms and quaternary salts

Chemistry of Natural Compounds Aims and scope

Summary

1. Salsoline, salsolidine, ephedrine, pseudoephedrine, tetrahydroquinoline, and decahydroquinoline have been condensed with ethylene oxide and the corresponding amino alcohols have been obtained.

2. The conformational states and spatial structures of the compounds synthesized and their protonated forms and methiodides have been studied by IR and PMR spectroscopy. It has been shown that because of the rapid conversion of the saturated parts of the molecules of the bases and inversion processes, several stable spatial forms of the N-derivatives with quarternized nitrogen atoms exist in solutions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. I. A. Primukhamedov, K. H. Aslanov, and A. S. Sadykov, in: Proceedings of a Jubilee Scientific Conference at Tashkent Pharmaceutical Institute Devoted to the 50th Anniversary of Soviet Power [in Russian], Tashkent (1967).

  2. I. A. Primukhamedov, K. H. Aslanov, and A. S. Sadykov, Uzb. Khim. Zh., No. 4, 57 (1969).

  3. A. L. Takhtadzhyan, System and Phylogeny of Flowering Plants [in Russian], Moscow-Leningrad (1968), p. 293.

  4. I. A. Primukhamedov, Z. É. Madrakhimov, S. A. Tursunov, A. A. Alikhodzhaev, and S. Kh. Masyrov, in: Proceedings of a Jubilee Scientific Conference Devoted to the Centenary of the Birth of V. I. Lenin [in Russian], Tashkent (1970).

  5. W. Ross, Biological Alkylating Agents, Butterworth, London (1962).

    Google Scholar 

  6. L. F. Larionov, The Chemotherapy of Malignant Tumors [in Russian], Moscow (1962).

  7. I. M. Peisakhovich, et al., The Chemotherapy of Malignant Tumors [in Russian], Kiev.

  8. N. I. Perevodchikov, Medicinal Methods of Treating Malignant Tumors [in Russian], Moscow (1961).

  9. V. N. Konyukhov and Z. V. Pushkareva, Zh. Obshch. Khim.,31, No. 9, 2914 (1961).

    Google Scholar 

  10. T. K. Yunusov, T. K. Kasymov, F. G. Kamaev, V. B. Leont'ev, A. I. Ishbaev, K. Inoyatova, and A. S. Sadykov, Khim. Prirodn. Soedin., 448 (1971).

  11. T. M. Moynehan, K. Schofield, R. A. J. Jones, and A. R. Katritzky, J. Chem. Soc., 2637 (1962).

  12. G. Kundel', Hydration and Intramolecular Interaction [in Russian], Moscow (1972).

Download references

Authors

Additional information

V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 486–492, July–August, 1974.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karimov, M., Levkovich, M.G., Leont'ev, V.B. et al. Study of the conformational states of amino-alcohol derivatives of some alkaloids and bases and their protonated forms and quaternary salts. Chem Nat Compd 10, 490–495 (1974). https://doi.org/10.1007/BF00563816

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00563816

Keywords

Navigation