Abstract
The present work demonstrates the utility of packed bed reactors for the production of monoclonal antibody. We present data from a continuous process run for the production of over 100 grams of antibody, using serum-free medium. An additional pilot run also demonstrates the potential for continued antibody production under protein-free conditions, using a standard basal medium.
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Bliem, R., Oakley, R., Matsuoka, K. et al. Antibody production in packed bed reactors using serum-free and protein-free medium. Cytotechnology 4, 279–283 (1990). https://doi.org/10.1007/BF00563788
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DOI: https://doi.org/10.1007/BF00563788