Synthesis and properties of the methyl ester of polyuridylyl-(5′→ N)-phenylalanine
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1. The methyl ester of polyuridylyl-(5′→N)-phenylalanine containing an average of 13 nucleotide residues has been synthesized by the carbodiimide method.
2. The hydrolysis of the methyl ester of polyuridylyl-(5′→N)-phenylalanine has been studied as functions of pH and time. In this compound, the phosphoric amide bond is hydrolyzed in an acid medium and is stable at pH<4, and the half-period of hydrolysis of the phosphoric amide bond in 0.05 N hydrochloric acid solution is 20 min.
KeywordsMethyl Ester Phenylalanine Hydrochloric Acid Solution Caustic Potash Absolute Ether
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- 1.T. S. Ryabova et al., DAN SSSR, 153, 363, 1963.Google Scholar
- 2.A. M. Michelson, J. Chem. Soc., 1371, 1959.Google Scholar
- 3.A. S. Spirin and A. N. Belozerskii, Biokhim., 21, 768, 1956.Google Scholar
- 4.O. E. Vorob'ev, A. Shabarova, and M. A. Prokof'ev, DAN SSSR, 158, 143, 1964; ZhOKh, 34, 359, 1964.Google Scholar
- 5.O. E. Vorob'ev et al., DAN SSSR, 163, 1402, 1965.Google Scholar
- 6.H. G. Khorana, Some Recent Developments in the Chemistry of Phosphate Esters of Biological Interest [Russian translation], Moscow, 1964.Google Scholar
- 7.T. S. Ryabova, Z. A. Shabarova, and M. A. Prokof'ev, Vestnik MGU, ser. khim., 5, 100, 1965.Google Scholar
- 8.O. E. Vorob'ev, Z. A. Shabarova, and M. A. Prokof'ev, Vestnik MGU, ser. khim., 6, 66, 1964.Google Scholar
- 9.A. M. Michelson, J. Chem. Soc., 1957, 1958.Google Scholar
- 10.G. N. Zaitseva and N. P. Tyuleneva, Lab. delo, 3, 24, 1958.Google Scholar