Advertisement

Chemistry of Natural Compounds

, Volume 10, Issue 2, pp 238–243 | Cite as

Synthesis of new analogs of valinomycin and their properties. I

  • E. I. Vinogradova
  • L. A. Fonina
  • A. A. Sanasaryan
  • I. D. Ryabova
  • V. T. Ivanov
Article

Conclusions

1. The synthesis of five valinomycin analogs differing by the configurations of the amino-acid and hydroxy-acid residues and also by the volumes of the radicals of the hydroxy-acid residues has been effected.

2. The stability constants of the complexes of these analogs with potassium ions in ethanol solution have been determined.

3. The antimicrobial activities of the compounds obtained have been studied and a correlation has been found between the degree of activity and stability of the complexes with K+.

Keywords

Magnesium Sulfate Valinomycin Sulfonyl Chloride Anhydrous Pyridine Palladium Black 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    M. M. Shemyakin, E. I. Vinogradova, M. Yu. Feigina, N. A. Aldanova, Yu. B. Shvetsov, and L. A. Fonina, Zh. Obshch. Khim.,36, 1391 (1966).Google Scholar
  2. 2.
    V. T. Ivanov, I. A. Laine, I. D. Ryabova, and Yu. A. Ovchinnikov, Khim. Prirodn. Soedin., 744 (1970).Google Scholar
  3. 3.
    L. A. Fonina, A. A. Sanasaryan, and E. I. Vinogradova, Khim. Prirodn. Soedin., 69 (1971).Google Scholar
  4. 4.
    A. A. Sanasaryan, L. A. Fonina, Yu. B. Shvetsov, and E. I. Vinogradova, Khim. Prirodn. Soedin., 81 (1971).Google Scholar
  5. 5.
    M. M. Shemyakin, E. I. Vinogradova, M. Yu. Feigina, N. A. Aldanova, N. F. Loginova, I. D. Ryabova, and I. A. Pavlenko, Exper.,21, 548 (1965).Google Scholar
  6. 6.
    M. M. Shemyakin, E. I. Vinogradova, I. D. Ryabova, L. A. Fonina, and A. A. Sanasaryan, Khim. Prirodn. Soedin., 241 (1973).Google Scholar
  7. 7.
    M. M. Shemyakin, Yu. A. Ovchinnikov, V. T. Ivanov, V. K. Antonov, E. I. Vinogradova, A. M. Shkrob, G. G. Malenkov, A. V. Evstratov, I. A. Laine, E. I. Melnik, and I. D. Ryabova, J. Membrane Biol.,1, 402 (1969).CrossRefGoogle Scholar
  8. 8.
    E. I. Mel'nik, A. V. Babakov, and A. M. Shkrob, Symposium on “The Biophysics of Membranes,” Palanga (1971) [in Russian], Kaunas, Part 1 (1971), p. 599.Google Scholar
  9. 9.
    Yu. A. Ovchinnikov, Pure Appl. Chem.,2, 123 (1971).Google Scholar
  10. 10.
    V. T. Ivanov, I. A. Laine, Yu. A. Ovchinnikov, I. I. Chervin, and G. I. Yakovlev, Khim. Prirodn. Soedin., 248 (1973).Google Scholar
  11. 11.
    B. C. Das, S. D. Gero, and E. Lederer, Biochem. Biophys. Res. Commun.,29, 211 (1967).CrossRefGoogle Scholar
  12. 12.
    G. A. Gorneva, I. D. Ryabova, and G. Faizova, Symposium on “The Biophysics of Membranes,” Palanga (1971) [in Russian], Kaunas, Part 1 (1971), p. 318.Google Scholar
  13. 13.
    F. L. Garrity, B. Detrick, and E. R. Kennedy, J. Bacteriology,97, 557 (1969).Google Scholar
  14. 14.
    O. O. Makeeva, in: Methods of Experimental Chemotherapy (Tuberculosis) [in Russian], Moscow (1959), p. 148.Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • E. I. Vinogradova
  • L. A. Fonina
  • A. A. Sanasaryan
  • I. D. Ryabova
  • V. T. Ivanov

There are no affiliations available

Personalised recommendations