Chemistry of Natural Compounds

, Volume 6, Issue 5, pp 612–615 | Cite as

Solid-phase synthesis of a nonapeptide corresponding to sequence 26–34 of cytochrome B5

  • V. M. Kozhukhovskaya
  • S. D. L'vova
  • R. P. Evstigneeva


1. The hydrobromide of Nɛ-tosyl-L-lysyl-L-phenylalanyl-L-leucyl-L-glutamyl-L-glutamyl-Nim-benzyl-L-histidyl-L-orolylglycylglycine, corresponding to sequence 26–34 of cytochrome B5, has been synthesized by the solid-phase method.

2. The lability of the bond between proline and the amino acids adjacent to it under the conditions of the splitting off of the peptide from the resin has been shown.


Dipeptide Hydrobromide Caustic Soda Sodium Bicarbonate Solution Benzyl Ester 


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Literature cited

  1. 1.
    P. Strittmatter, J. Biol. Chem.,235, 2492 (1960).PubMedGoogle Scholar
  2. 2.
    J. Osols and P. Strittmatter, J. Biol. Chem.,243, 3367 (1968).Google Scholar
  3. 3.
    G. R. Marshall and R. B. Merrifield, Biochem.,4, 2394 (1965).CrossRefGoogle Scholar
  4. 4.
    J. Blake and Choh Hao Li, J. Am. Chem. Soc.,90, 5882 (1968).CrossRefGoogle Scholar
  5. 5.
    V. A. Shibnev, T. D. Kozarenko, and K. T. Poroshin, Izv. AN SSSR, Ser. Khim., 1500 (1960).Google Scholar
  6. 6.
    H. C. Beyerman, C. A. M. Boers Bonnekamp, and H. Maasen Van der Brink-Zimmermannova, Rec. Trav. Chim.,87, 257 (1968).CrossRefGoogle Scholar
  7. 7.
    L. C. Dorman and E. C. Britton, Tetrah. Let., 2319 (1969).Google Scholar
  8. 8.
    K. T. Poroshin, V. A. Shibnev, V. G. Debabov, and T. D. Kozarenko, Biokhim.,25, 693 (1960).Google Scholar
  9. 9.
    H. Rosen, Arch. Biochem., Biophys.,67, 10 (1957).CrossRefGoogle Scholar
  10. 10.
    L. Zervas and T. U. Theodoropoulos, J. Am. Chem. Soc.,78, 1359 (1956).CrossRefGoogle Scholar

Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1973

Authors and Affiliations

  • V. M. Kozhukhovskaya
  • S. D. L'vova
  • R. P. Evstigneeva

There are no affiliations available

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