The modification of nucleosides and their 5′-phosphates by Nα, Nα, Nε, Nε-tetramethyllysine hydrazide
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Nα, Nα, Nɛ, Nɛ-Tetramethyllysine hydrazide, its derivatives with oxidized nucleosides, and their 5′-phosphates have been synthesized. The stabilities of the modification products and the influence of the introduction of the hydrazide on the chromatographic properties of model compounds have been characterized. The possibility is discussed of using Nα, Nα, Nɛ, Nɛ-tetramethyllysine hydrazide as a specific 3′-terminal modifying agent for RNA.
KeywordsNucleoside Hydrazide Hydrazine Hydrate Isonicotinic Acid Chromatographic Property
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