Summary
Langerhans cells in the epidermis at the sites of vaccinia virus inoculation were studied with the electron microscope. The cells contained unusually increased numbers of the Langerhans cell granules. Such abnormal Langerhans cells have not been described except for in histiocytosis X. Vaccinia virus particles were found in the Langerhans cells, where they were located individually or embedded in the granular matrix or in lysosomes.
Zusammenfassung
Langerhans-Zellen in der Epidermis der Impfpapeln nach der Pockenimpfung wurden elektronenmikroskopisch untersucht. Diese Zellen hatten ungewöhnlich zahlreiche Langerhans-Zell-Granula, die oft abnorme Konfigurationen zeigten. Solche Langerhans-Zellen sind bisher nicht beschrieben worden, außer bei der Histiocytose X. Die Vakzinviren wurden in den Langerhans-Zellen gefunden, wo die Viren isoliert oder in den granulären Matrizen bzw. in den Lysosomen existierten.
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Nagao, S., Inaba, S. & Iijima, S. Langerhans cells at the sites of vaccinia virus inoculation. Arch. Derm. Res. 256, 23–31 (1976). https://doi.org/10.1007/BF00561177
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DOI: https://doi.org/10.1007/BF00561177