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Allgemeiner immunstatus bei patienten mit generalisiertem lichen ruber planus

Immunological investigations in lichen planus patients

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Summary

30 patients suffering from generalized lichen planus (= L.p.) have been examined by the following methods in order to obtain more precise information regarding their immune-status:

  1. 1.

    Quantitative determination of immuno-globulins including complement fraction (β 1C/A)

  2. 2.

    Intracutaneous tests with recall-antigens

  3. 3.

    Investigation of cutaneous sensitivity to DNCB

  4. 4.

    Lymphocytemigrationinhibition- and Lymphocytetransformationstests.

The results obtained were not statistically significant when comparing the results of this investigation in patients suffering from L.p. with the control group. Therefore, the theory that immunological processes are the basis of these occurences is still under discussion. Further studies applying more specific methods should be conducted in order to clarify this problem.

Zusammenfassung

Bei 30 Patienten mit generalisiertem Lichen ruber planus (L.r.pl.) wurden folgende Untersuchungen durchgeführt, um Informationen über den allgemeinen, immunologischen Status zu erhalten:

  1. 1.

    Quantitative Bestimmung der Immunglobuline und Komplementfraktion (β 1C/A)

  2. 2.

    Intrakutanteste mit Recall-Antigenen

  3. 3.

    Prüfung der percutanen Sensibilisierbarkeit gegen DNCB

  4. 4.

    Lymphozytenmigrations- und -transformationstests.

Die Auswertung der Untersuchungsresultate ergab keine statistisch signifikanten Unterschiede zwischen Lichen ruber-Patienten und Kontrollgruppe. Dadurch läßt sich die Annahme, daß dem L.r.pl. immunologische Vorgänge zugrunde liegen, nicht entkräften; weitere Studien mit spezifischeren Methoden wären zur Klärung dieser Frage erforderlich.

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Author information

Authors and Affiliations

  1. Inst. für Krebsforschung der Univ., Broschkegasse 8a, A-1090, Wien, Germany

    Christa Cerni

  2. II. Univ.-Hautklinik, Alserstraße 4, A-1090, Wien, Germany

    Christa Cerni, H. Ebner & Eva-Maria Kokoschka

Authors
  1. Christa Cerni
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  2. H. Ebner
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  3. Eva-Maria Kokoschka
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Mit Unterstützung des Fonds zur Förderung der wissenschaftlichen Forschung in Österreich.

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Cerni, C., Ebner, H. & Kokoschka, EM. Allgemeiner immunstatus bei patienten mit generalisiertem lichen ruber planus. Arch. Derm. Res. 256, 13–22 (1976). https://doi.org/10.1007/BF00561176

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