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Preparation of N-arylamino-2-pyrrolidones from arylhydrazides of γ-chlorobutyric acid

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Intramolecular alkylation of the arylhydrazides of γ-chlorobutyric acid in the presence of sodium ethoxide leads to the formation of N-arylamino-2-pyrrolidones. The direction of the reaction is not altered by the absence of a substituent on the aniline nitrogen atom. In the case of a p-nitrophenyl-hydrazide, O-alkylation is observed.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 142450, Staraya Kupavna

    A. V. Blokhina, V. G. Boronin, V. V. Druzhinina, V. P. Zhestkov & Yu. N. Portnov

Authors
  1. A. V. Blokhina
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  2. V. G. Boronin
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  3. V. V. Druzhinina
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  4. V. P. Zhestkov
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  5. Yu. N. Portnov
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 474–478, April, 1987.

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Blokhina, A.V., Boronin, V.G., Druzhinina, V.V. et al. Preparation of N-arylamino-2-pyrrolidones from arylhydrazides of γ-chlorobutyric acid. Chem Heterocycl Compd 23, 395–399 (1987). https://doi.org/10.1007/BF00546732

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  • DOI: https://doi.org/10.1007/BF00546732

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