Abstract
The reduction of 5-hydroxy-5-methyl-4-oxo-3-phenylpyrrolidino[1,2-b]pyrazole by heating with hydrazine hydrate in alkaline solution is accompanied by fission of the bicyclic skeleton or by dehydration depending on the solvent and reaction temperature. A two-stage synthesis of 6,6-dimethyl-3-phenyl-pyrrolidino[1,2-b]pyrazole from 5-hydroxy-6,6-dimethyl-4-oxo-3-phenylpyrrolidino[1,2-b]pyrazole is proposed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1345–1348, October, 1993.
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Kuz'menok, N.M., Zvonok, A.M. Wolff-kishner reduction of 5-methyl- and 6,6-dimethyl-5-hydroxy-4-oxo-3-phenylpyrrolidino-[1,2-b]pyrazoles. Chem Heterocycl Compd 29, 1152–1155 (1993). https://doi.org/10.1007/BF00538059
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DOI: https://doi.org/10.1007/BF00538059