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Synthesis of imidazo[4,5-e][1,4]diazepine-8-one

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

We have developed a method for synthesis of 1-methyl-4,5,7, 8-tetrahydro-6H-imidazo[4,5-e][1,4]diazepin-8-one. We have shown that in intramolecular cyclization of N-(2-hydroxyethyl)- or N-(2-chloroethyl)amides of 1-methyl-4-aminoimidazolyl-5-carboxylic acids it is not the corresponding tetrahydroimidazo[4,5-e][1,4]diazepin-8-ones which are formed but rather the isomeric 4-amino-5-(oxazolin-2-yl)imidazoles.

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Authors and Affiliations

  1. A. V. Bogatskii Physical Chemistry Institute, Academy of Sciences of Ukraine, 270080, Odessa

    G. D. Kalayanov, É. I. Ivanov & L. V. Grishchuk

Authors
  1. G. D. Kalayanov
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  2. É. I. Ivanov
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  3. L. V. Grishchuk
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1203–1206, September, 1993.

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Kalayanov, G.D., Ivanov, É.I. & Grishchuk, L.V. Synthesis of imidazo[4,5-e][1,4]diazepine-8-one. Chem Heterocycl Compd 29, 1026–1029 (1993). https://doi.org/10.1007/BF00534386

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  • DOI: https://doi.org/10.1007/BF00534386

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