Chemistry of Heterocyclic Compounds

, Volume 29, Issue 8, pp 945–948 | Cite as

Synthesis of a new potential antiviral agent — 9-allyloxymethylguanine

  • A. A. Ozerov
  • A. K. Brel'


A convenient method has been developed for the synthesis of 9-allyloxymethylguanine. The direct alkylation of the trimethylsilyl derivative of guanine allyloxymethyl chloride gives a 64% yield of 9- and 7-allyloxymethylguanine (3∶1). A mixture of 9- and 7-allyloxymethyl-N-acetylguanine (7∶4) can be obtained in 56% yield by the condensation of diacetylguanine with allyloxymethyl acetate in dimethyl sulfoxide in the presences of p-toluenesulfonic acid.


Acetate Chloride Organic Chemistry Dimethyl Sulfoxide 
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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • A. A. Ozerov
    • 1
  • A. K. Brel'
    • 1
  1. 1.Scientific-Research Institute of Pharmacology at Volgograd Medical Institute MZ RFVolgograd

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