Chemistry of Heterocyclic Compounds

, Volume 29, Issue 8, pp 941–944 | Cite as

4-Hydroxy-2-quinolones. 16. Condensation of N-R-substituted amides of 2-carboxymalonanilic acid with o-phenylenediamine

  • I. V. Ukrainets
  • S. G. Taran
  • A. V. Turov


The reaction of N-R-substituted amides of 2-carboxymalonanilic acid with the equimolar amount of o-phenylenediamine was studied under conditions of thermolysis. It was established that the main products of this reaction are the corresponding amides of benzimidazolyl-2-acetic acid and 1H-2-oxo-3-(benzimidazolyl-2)-4-hydroxyquinoline. Mechanisms of the indicated chemical conversions are discussed. The data on the study of the anticonvulsive activity of the compounds synthesized are presented.


Organic Chemistry Amide Main Product Thermolysis Equimolar Amount 
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  1. 1.
    I. V. Ukrainets, S. G. Taran, O. A. Evtifeeva, and A. V. Turov, Khim. Geterotsikl. Soedin., No. 8, 1101 (1993).Google Scholar
  2. 2.
    E. Elderfild, Heterocyclic Compounds [Russian translation], Vol. 5, IL, Moscow (1961), p. 220.Google Scholar
  3. 3.
    D. S. Kanekar, A. N. Bedekar, and K. D. Deodhar, Indian J. Chem., 18B, 370 (1979).Google Scholar
  4. 4.
    I. M. Tekry, E. A. A. Momen, A. H. A. Hoda, and E. A. Samir, Tetrahedron, 44, 3757 (1988).Google Scholar
  5. 5.
    I. V. Ukrainets, P. A. Bezuglyi, V. I. Treskach, and A. V. Turov, Khim. Geterotsikl. Soedin., No. 2, 239 (1992).Google Scholar
  6. 6.
    L. N. Vostrova, T. A. Voronina, T. L. Karaseva, S. A. Gernega, É. I. Ivanov, A. M. Kirichenko, and M. Yu. Totrova, Khim. Farm. Zh., 20, 690 (1986).Google Scholar
  7. 7.
    M. D. Mashkovskii, Medicinal Agents [in Russian], Vol. 1, Meditsina, Moscow (1988), p. 147.Google Scholar
  8. 8.
    P. A. Bezuglyi, B. A. Samura, V. I. Treskach, I. V. Ukrainets, S. V. Shaporenko, and A. I. Maslennikov, Khar'kov State Pharm. Institute (KhGFI), Moscow (1987). Dep. in TsBNTIMedprom., 26.05.87, No. 4-MP.Google Scholar
  9. 9.
    P. O. Bezuglyi, I. V. Ukrainets, V. A. Georgiyants, V. I. Treskach, M. G. Sergienko, V. M. Savchenko, and O. V. Turov, Farm. Zh., No. 6, 35 (1990).Google Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • S. G. Taran
    • 1
  • A. V. Turov
    • 1
  1. 1.Ukrainian Pharmaceutical AcademyKhar'kov

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