Chemistry of Heterocyclic Compounds

, Volume 29, Issue 8, pp 938–940 | Cite as

4-Hydroxy-2-quinolines. 15. Synthesis of N-(2-pyridyl)amides of 1-R-4-hydroxy-2-quinolone-3-carboxylic acids as possible new non-steroidal antiinflammatory agents

  • I. V. Ukrainets
  • S. G. Taran
  • O. A. Evtifeeva
  • A. V. Turov


Different approaches to the reaction of ethyl 1-R-4-hydroxy-2-quinolone-3-carboxylates with 2-aminopyridine were studied. It was found that the most rational of them is the thermolysis of equimolar amounts of the amine and the corresponding ester. Data on the analgesic and antiinflammatory activity of the amides synthesized are presented.


Ester Ethyl Organic Chemistry Amide Antiinflammatory Activity 
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  1. 1.
    I. V. Ukrainets, V. A. Georgiyants, O. V. Gorokhova, P. A. Bezuglyi, L. F. Silaeva, I. L. Dikii, and O. A. Dolgopolaya, Ukr. Farmats. Akademiya, Khar'kov (1993). Dep. in UkrINTÉI 30.03.93, No. 708-UK 93.Google Scholar
  2. 2.
    Ya. A. Sigidin, G. Ya. Shvarts, A. P. Arzamastsev, and S. S. Liberman, Drug Therapy of the Inflammatory Process [in Russian], Meditsina, Moscow (1988), p. 240.Google Scholar
  3. 3.
    I. V. Ukrainets, P. A. Bezuglyi, V. I. Treskach, and A. V. Turov, Khim. Geterotsikl. Soedin., No. 5, 640 (1992).Google Scholar
  4. 4.
    I. V. Ukrainets, P. A. Bezuglyi, V. I. Treskach, A. V. Turov, Yu. F. Krylov, and N. P. Moryakov, Khim. Farm. Zh., 27 (1993).Google Scholar
  5. 5.
    Inventor's Certificate 1657496 USSR. P. A. Bezuglyi, V. I. Treskach, I. V. Ukrainets, and M. N. Smirnov, Byul. Izobret., No. 23 (1991).Google Scholar
  6. 6.
    K. Veigand and G. Khil'getag, Methods of Experiment in Organic Chemistry [in Russian], Khimiya, Moscow (1968), p. 455.Google Scholar
  7. 7.
    R. Maki and D. Smit, Guidebook to Organic Synthesis [Russian translation], Mir, Moscow (1985), p. 352.Google Scholar
  8. 8.
    A. F. Bochkov and V. A. Smit, Organic Synthesis [in Russian], Nauka, Moscow (1987), p. 304.Google Scholar
  9. 9.
    P. Sykes, Mechanisms of Reactions in Organic Chemistry [Russian translation], Khimiya, Moscow (1971), p. 280.Google Scholar
  10. 10.
    G. Ya. Shvarts and R. D. Syubaev, Farmakol. Toksikol., 45, No. 1, 46 (1982).Google Scholar
  11. 11.
    C. A. Winter, E. A. Risley, and G. W. Nuss, Proc. Soc. Exp. Biol. Med., 111, 544 (1962).Google Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • S. G. Taran
    • 1
  • O. A. Evtifeeva
    • 1
  • A. V. Turov
    • 1
  1. 1.Ukrainian Pharmaceutical AcademyKhar'kov

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