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Chemistry of Heterocyclic Compounds

, Volume 29, Issue 8, pp 938–940 | Cite as

4-Hydroxy-2-quinolines. 15. Synthesis of N-(2-pyridyl)amides of 1-R-4-hydroxy-2-quinolone-3-carboxylic acids as possible new non-steroidal antiinflammatory agents

  • I. V. Ukrainets
  • S. G. Taran
  • O. A. Evtifeeva
  • A. V. Turov
Article
  • 51 Downloads

Abstract

Different approaches to the reaction of ethyl 1-R-4-hydroxy-2-quinolone-3-carboxylates with 2-aminopyridine were studied. It was found that the most rational of them is the thermolysis of equimolar amounts of the amine and the corresponding ester. Data on the analgesic and antiinflammatory activity of the amides synthesized are presented.

Keywords

Ester Ethyl Organic Chemistry Amide Antiinflammatory Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • S. G. Taran
    • 1
  • O. A. Evtifeeva
    • 1
  • A. V. Turov
    • 1
  1. 1.Ukrainian Pharmaceutical AcademyKhar'kov

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