Chemistry of Heterocyclic Compounds

, Volume 28, Issue 11, pp 1323–1330 | Cite as

Nitroazines 18. Arylation and destruction of 6-nitro-1,2,4-triazolo[1,5-a]pyrimidines

  • V. L. Rusinov
  • M. N. Kushnir
  • O. N. Chupakhin
  • G. G. Aleksandrov


6-Ntiro-7-aryl-1,2,4-triazolo[1,5-a]pyrimidines were synthesized by treatment of the corresponding 7-oxo compounds with phosphorus oxychloride in the presence of N,N-dialkylanilines. The 7-(N-methyl-p-methoxyphenylamino) derivatives were formed under the same conditions with N,N-dimethyl-p-anisidine. The nitroarylazolopyrimidines produced underwent destruction to give ω-nitroacetophenones on treatment with water. The influence of substituenis on the course of the reaction is shown and the mechanism is discussed.


Phosphorus Organic Chemistry Pyrimidine Oxychloride Phosphorus Oxychloride 
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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • V. L. Rusinov
    • 1
  • M. N. Kushnir
    • 1
  • O. N. Chupakhin
    • 1
  • G. G. Aleksandrov
    • 1
  1. 1.Urals Polytechnical InstituteEkaterinburg

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