Abstract
The reaction of 8-bromo- and 8-dimethylaminotheophyllines with organic acid chlorides in the presence of tertiary aliphatic amines was investigated. The direction of the reactions depends on the nature of each of the three components. Depending on the combination, it is possible to obtain 7-acyl-8-bromo-, 7-benzoyl-8-dimethylamino-, and 7-alkenyl-8-dimethylaminotheophylline and 8-trimethylammoniotheophyllinate. A convenient method is proposed for the synthesis of the latter.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1539–1545, November, 1992.
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Bobkov, V.N., Zvolinskaya, T.V. & Kuz'menko, I.I. Reactions of theophyllines. Synthesis of 8-trimethylammoniotheophyllinate. Chem Heterocycl Compd 28, 1317–1322 (1992). https://doi.org/10.1007/BF00532086
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DOI: https://doi.org/10.1007/BF00532086