Chemistry of Heterocyclic Compounds

, Volume 28, Issue 11, pp 1317–1322 | Cite as

Reactions of theophyllines. Synthesis of 8-trimethylammoniotheophyllinate

  • V. N. Bobkov
  • T. V. Zvolinskaya
  • I. I. Kuz'menko


The reaction of 8-bromo- and 8-dimethylaminotheophyllines with organic acid chlorides in the presence of tertiary aliphatic amines was investigated. The direction of the reactions depends on the nature of each of the three components. Depending on the combination, it is possible to obtain 7-acyl-8-bromo-, 7-benzoyl-8-dimethylamino-, and 7-alkenyl-8-dimethylaminotheophylline and 8-trimethylammoniotheophyllinate. A convenient method is proposed for the synthesis of the latter.


Chloride Organic Chemistry Organic Acid Theophylline Convenient Method 
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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • V. N. Bobkov
    • 1
  • T. V. Zvolinskaya
    • 1
  • I. I. Kuz'menko
    • 1
  1. 1.Kiev Scientific-Research Institute of Pharmacology and ToxicologyKiev

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