Alkylation of 4-hydroxy-6-methyl-2-methylthio-pyrimidine with chloroacetonitrile
- 62 Downloads
The sodium salt of 4-hydroxy-6-methyl-2-methylthiopyrimidine is alkylated with chloroacetonitrile in hexamethyltriamidophosphate on the O-atom, and in dioxane or tetrahydrofuran on the N3-atom, with the formation of 6-methyl-2-methylthio-4-cyanomethoxypyrimidine and 6-methyl-2-methylthio-3-cyanomethyl-4-pyrimidone, respectively.
KeywordsSodium Organic Chemistry Alkylation Dioxane Tetrahydrofuran
Unable to display preview. Download preview PDF.
- 1.P. I. Vainilavichyus and V. Yu. Syadyaryavichyushe, Zh. Geterotsikl. Khim., No. 11, 1520 (1987).Google Scholar
- 2.P. I. Vainilavichyus and V. Yu. Syadyaryavichyushe, Zh. Geterotsikl. Khim., No. 12, 1655 (1987).Google Scholar
- 3.H. L. Wheeler and H. F. Merriam, Am. J. Chem., 29, 478 (1903).Google Scholar
- 4.J. P. Jonak, G. C. Hopkins, H. J. Minnemeyer, and H. Tieckelman, J. Org. Chem., 35, 2512 (1970).Google Scholar