Advertisement

Chemistry of Heterocyclic Compounds

, Volume 28, Issue 11, pp 1304–1306 | Cite as

Alkylation of 4-hydroxy-6-methyl-2-methylthio-pyrimidine with chloroacetonitrile

  • V. Syadyaryavichyute
  • P. Vainilavichyus
Article

Abstract

The sodium salt of 4-hydroxy-6-methyl-2-methylthiopyrimidine is alkylated with chloroacetonitrile in hexamethyltriamidophosphate on the O-atom, and in dioxane or tetrahydrofuran on the N3-atom, with the formation of 6-methyl-2-methylthio-4-cyanomethoxypyrimidine and 6-methyl-2-methylthio-3-cyanomethyl-4-pyrimidone, respectively.

Keywords

Sodium Organic Chemistry Alkylation Dioxane Tetrahydrofuran 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P. I. Vainilavichyus and V. Yu. Syadyaryavichyushe, Zh. Geterotsikl. Khim., No. 11, 1520 (1987).Google Scholar
  2. 2.
    P. I. Vainilavichyus and V. Yu. Syadyaryavichyushe, Zh. Geterotsikl. Khim., No. 12, 1655 (1987).Google Scholar
  3. 3.
    H. L. Wheeler and H. F. Merriam, Am. J. Chem., 29, 478 (1903).Google Scholar
  4. 4.
    J. P. Jonak, G. C. Hopkins, H. J. Minnemeyer, and H. Tieckelman, J. Org. Chem., 35, 2512 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • V. Syadyaryavichyute
    • 1
  • P. Vainilavichyus
    • 1
  1. 1.Vilnius UniversityVilnius

Personalised recommendations