Abstract
3-Ethoxycarbonylquinuclidine obtained by the Grob method is a mixture of 3-ethoxycarbonyl-1-azabicylo-[2.2.2]- and, according to 13C NMR data, 5-ethoxycarbonyl-5-azatricyclo[3.2.1.02,7]octanes (∼16∶2∶1). 3-Ethoxy-carbonylquinuclidine was purified by recrystallization of the hydrochloride, hydrolyzed by water to 3-quinuclidinecarboxylic acid, and reduced by LiAlH4 to 3-quinuclidinylmethanol.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, 1509–1512, November, 1992.
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Koikov, L.N., Lisitsa, E.A., Alekseeva, N.A. et al. Purification of 3-ethoxycarbonylquinuclidine and its conversion to 3-quinuclidinecarboxylic acid and 3-quinuclidinylmethanol. Chem Heterocycl Compd 28, 1289–1292 (1992). https://doi.org/10.1007/BF00532080
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DOI: https://doi.org/10.1007/BF00532080