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Chemistry of Heterocyclic Compounds

, Volume 28, Issue 11, pp 1286–1288 | Cite as

Synthesis of amides of 2-arylamino-4,6-dimethylnicotinic acid

  • L. M. Demina
  • M. Yu. Gavrilov
  • S. N. Shurov
  • M. E. Konshin
Article
  • 34 Downloads

Abstract

The amides of 2-arylamino-4,6-dimethyl-2-chloronicotinic acid have been prepared. It has been shown that on account of steric hindrance on the part of the methyl group on the C(4) atom the conjugation of the amide function with the pyridine ring is broken and its influence on the mobility of the halogen is weakened, and the compound enters into a given reaction with more difficulty than its 6-monomethyl homolog.

Keywords

Methyl Organic Chemistry Amide Pyridine Halogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • L. M. Demina
    • 1
    • 2
  • M. Yu. Gavrilov
    • 1
    • 2
  • S. N. Shurov
    • 1
    • 2
  • M. E. Konshin
    • 1
    • 2
  1. 1.Perm Pharmaceutical InstitutePerm
  2. 2.Perm M. Gorkii State UniversityPerm

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