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Metallation of 1-dialkylaminobenzimidazoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

In contrast to 1-amino- and 1-alkylaminobenzimidazoles, 1-di-alkylaminobenzimidazoles are metallated by n-butyl-lithium in absolute either at the 2-position. The subsequent treatment of the lithium derivatives by electrophilic reagents, in which role benzophenone and iodine were used, leads to the formation of the corresponding 2-R-1-dialkylaminobenzimidazoles, which are difficult to obtain by other methods. The possibility was studied of using the N-dialkylamino group as a protective function.

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Authors and Affiliations

  1. Scientific-Research Institute of Physical and Organic Chemistry of the Rostov State University, 344006, Rostov-on-Don

    V. V. Kuz'menko, I. A. Filatova & A. F. Pozharskii

Authors
  1. V. V. Kuz'menko
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  2. I. A. Filatova
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  3. A. F. Pozharskii
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1196–1201, September, 1992.

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Kuz'menko, V.V., Filatova, I.A. & Pozharskii, A.F. Metallation of 1-dialkylaminobenzimidazoles. Chem Heterocycl Compd 28, 1009–1014 (1992). https://doi.org/10.1007/BF00531477

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  • DOI: https://doi.org/10.1007/BF00531477

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