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Chemistry of Heterocyclic Compounds

, Volume 28, Issue 12, pp 1411–1415 | Cite as

Reactions of nucleophilic substitution of 4-aryl-5-carbomethoxy-6-methyl-2-chloro-3-cyanopyridines

  • Z. A. Kalme
  • B. Roloff
  • Yu. E. Pelcher
  • Yu. Yu. Popelis
  • F. Khagen
  • G. Ya. Dubur
Article

Abstract

Methods of synthesis of 5-carbomethoxy-substituted pyrazolo[3,4-b]pyridines and 3H-imidazo[4,5-b]pyridines by their reaction with hydrazine hydrate or as a result of Hofmann rearrangement of the corresponding 2-aminopyridines were developed based on 4-aryl-3-carbamoyl(or cyano)-5-carbomethoxy-6-methyl-2-chloropyridines.

Keywords

Hydrate Organic Chemistry Pyridine Hydrazine Cyano 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Z. A. Kalme, B. Roloff, Yu. Yu. Pelcher, Yu. Yu. Popelis, F. Khagen, and G. Ya. Dubur, Khim. Geterotsikl. Soedin., No. 9, 1218 (1992).Google Scholar
  2. 2.
    B. Roloff, J. S. Schafer, A. Rumler, and A. Hagen, Pharmazie, 44, 12 (1989).Google Scholar
  3. 3.
    V. Hagen, E. Klauschen, A. Rumler, A. Hagen, S. Heer, R. Mitzner, H. Niedrich, and D. Lohmann, Pharmazie, 45, 189 (1990).Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Z. A. Kalme
    • 1
    • 2
  • B. Roloff
    • 1
    • 2
  • Yu. E. Pelcher
    • 1
    • 2
  • Yu. Yu. Popelis
    • 1
    • 2
  • F. Khagen
    • 1
    • 2
  • G. Ya. Dubur
    • 1
    • 2
  1. 1.Latvian Institute of Organic SynthesisRiga
  2. 2.Institut für WirkstofforschungBerlin

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