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Chemistry of Heterocyclic Compounds

, Volume 28, Issue 12, pp 1402–1405 | Cite as

Synthesis of 3-methyl-4-cyano-3-butenoic acid amides and their cyclization into 6-amino-2-pyridones

  • Yu. S. Tsizin
  • O. B. Kuklenkova
  • B. V. Lopatin
  • N. K. Bebris
Article
  • 45 Downloads

Abstract

Two groups of amides, derivatives of 3-methyl-4-cyano- and 3-methyl-4-cyano-4-carbethoxy-3 acids were obtained from acetoacetamides in the form of mixtures of Z, E-isomers and the pure E-isomers were isolated. It was shown that amides from the first group are cyclized by bases into the corresponding 6-amino-4-methyl-2-pyridones and amides from the second group are cyclized into 6-hydroxy-5-cyano-4-methyl-2-pyridones.

Keywords

Organic Chemistry Amide Acid Amide Acetoacetamides 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Yu. S. Tsizin
    • 1
  • O. B. Kuklenkova
    • 1
  • B. V. Lopatin
    • 1
  • N. K. Bebris
    • 1
  1. 1.E. I. Martsinovskii Institute of Medical Parasitology and Tropical MedicineMoscow

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