Chemistry of Heterocyclic Compounds

, Volume 28, Issue 12, pp 1402–1405 | Cite as

Synthesis of 3-methyl-4-cyano-3-butenoic acid amides and their cyclization into 6-amino-2-pyridones

  • Yu. S. Tsizin
  • O. B. Kuklenkova
  • B. V. Lopatin
  • N. K. Bebris


Two groups of amides, derivatives of 3-methyl-4-cyano- and 3-methyl-4-cyano-4-carbethoxy-3 acids were obtained from acetoacetamides in the form of mixtures of Z, E-isomers and the pure E-isomers were isolated. It was shown that amides from the first group are cyclized by bases into the corresponding 6-amino-4-methyl-2-pyridones and amides from the second group are cyclized into 6-hydroxy-5-cyano-4-methyl-2-pyridones.


Organic Chemistry Amide Acid Amide Acetoacetamides 
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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Yu. S. Tsizin
    • 1
  • O. B. Kuklenkova
    • 1
  • B. V. Lopatin
    • 1
  • N. K. Bebris
    • 1
  1. 1.E. I. Martsinovskii Institute of Medical Parasitology and Tropical MedicineMoscow

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