Abstract
The reaction of aldehydes and ketones with 1,2,4-trimethylthiosemicarbazide in chloroform in the presence of CF3COOH gives the corresponding 1,2,4-triazolidine-3-thiones, which in an excess of trifluoroacetic acid irreversibly and quantitatively recyclize to 2-imino-1,3,4-thiadiazolidine derivatives.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 403–407, March, 1992.
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Zelenin, K.N., Kuznetsova, O.B. & Alekseev, V.V. 1,2,4-Trimethyl-1,2,4-triazolidine-3-thiones and 3,4-dimethyl-2-methylimino-1,3,4-thiadiazolidines. Chem Heterocycl Compd 28, 340–343 (1992). https://doi.org/10.1007/BF00529383
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DOI: https://doi.org/10.1007/BF00529383