Chemistry of Heterocyclic Compounds

, Volume 28, Issue 3, pp 321–323 | Cite as

Some nucleophilic substitution reactions of s-triazolo[1,5-c]pyrimidines

  • L. N. Dianova
  • T. G. Koksharova
  • N. V. Volkova


Nucleophilic substitution of 5-methylthio- and 5-cyanomethylthio-7-amino-s-triazolo[1,5-c]pyrimidines has been carried out using sodium hydroxide, ammonia, hydrazine hydrate, and four amines. The cyanomethyl group is particularly reactive under these conditions and 5-cyanomethylthiotriazolopyrimidine can be used to functionalize this heterocycle.


Sodium Ammonia Hydrate Hydroxide Organic Chemistry 
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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • L. N. Dianova
    • 1
  • T. G. Koksharova
    • 1
  • N. V. Volkova
    • 1
  1. 1.S. M. Kirov Polytechnic InstituteEkaterinburg

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