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Polyfunctional macroheterocycles. 7. Synthetic enzyme analogs. synthesis of 16- and 22-membered nitrogen and sulfur crown compounds containing exocyclic histamine and histidine fragments and carboxyl groups

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The acid hydrolysis of 9,14-bis(2-methoxycarbonylethyl)-11-12-benzo-3,4-(4′,5′-dimethylbenzo)-10,13-dioxo-1,6-dithia-9,14-diazacyclohexadeca-3,11-diene leads to the corresponding 9,14-biscarboxy derivative. The reaction of 4,9,15,20-tetrakis-(2-methoxycarbonylethyl)-6,7,17,18-dibenzo-5,8,16,19-tetraoxo-1,12-dithia-4,9,15,20-tetraazacyclodocosa-6,17-diene with hydrazine hydrate and subsequent treatment with NaNO2 gave the corresponding tetraazide. The reaction of this tetraazide with histamine and histidine leads to macroheterocycles, containing exocyclic histamine and histidine fragments.

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Authors and Affiliations

  1. Irkutsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 664033, Irkutsk

    M. G. Voronkov, V. N. Knutov, O. N. Shevko & M. K. Butin

Authors
  1. M. G. Voronkov
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  2. V. N. Knutov
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  3. O. N. Shevko
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  4. M. K. Butin
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Additional information

For Communication 6, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 130–133, January, 1993.

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Voronkov, M.G., Knutov, V.N., Shevko, O.N. et al. Polyfunctional macroheterocycles. 7. Synthetic enzyme analogs. synthesis of 16- and 22-membered nitrogen and sulfur crown compounds containing exocyclic histamine and histidine fragments and carboxyl groups. Chem Heterocycl Compd 29, 115–118 (1993). https://doi.org/10.1007/BF00528648

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  • DOI: https://doi.org/10.1007/BF00528648

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