Abstract
A method has been developed for the synthesis of derivatives of oxazolidin-5-one by the reaction of the corresponding N-benzyloxycarbonylaminoacid with formaldehyde in the presence of formic acid. Yields of derivatives of 3-benzyloxycarbonyloxazolidin-5-one increase with increased molecular weight of the initial compound. For the synthesis of 3-benzyloxycarbonyl-4-benzyloxazolidin-5-one the proposed method gives a higher yield than previously known methods. The reaction mechanism is discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 115–117, January, 1993.
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Katkevich, M.Y., Sile, D.É., Slavinska, V.A. et al. Synthesis of derivatives of oxazolidin-5-ones. Chem Heterocycl Compd 29, 100–102 (1993). https://doi.org/10.1007/BF00528645
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DOI: https://doi.org/10.1007/BF00528645