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Ureido and thioureido derivatives of β-lactam antibiotics

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

6-Ureido- and 6-thioureidopenicillanic acids and 7-ureido- and 7-thioureidodeacetoxycephalosporanic acids were obtained by the reaction of 6-aminopenicillanic acid and 7-aminodeacetoxycephalosporanic acids with tetraisocyanatosilane or tetraisothiocyanatosilane. N-Carbamoyl derivatives of ureido- and thioureidopenicillanic acids were isolated after repeated treatment of 6-ureido- and 6-thioureidopenicillanic acids with the indicated isocyanatosilanes.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226059, Riga

    L. N. Petrulyanis, G. A. Veinberg, L. I. Kononov, I. V. Dipan & É. Ya. Lukevits

Authors
  1. L. N. Petrulyanis
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  2. G. A. Veinberg
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  3. L. I. Kononov
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  4. I. V. Dipan
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  5. É. Ya. Lukevits
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 786–789, June, 1983.

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Petrulyanis, L.N., Veinberg, G.A., Kononov, L.I. et al. Ureido and thioureido derivatives of β-lactam antibiotics. Chem Heterocycl Compd 19, 630–634 (1983). https://doi.org/10.1007/BF00523074

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  • DOI: https://doi.org/10.1007/BF00523074

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