Abstract
The Demjanov rearrangement with ring expansion proceeds to a slight degree (∼9%) during the deamination of 1-methyl-2-aminomethylpiperidine with nitrous acid, and the major reaction products are 1-methyl-2-hydroxymethylpiperidine and 6-methylamino-2-hexanone.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1654–1658, December, 1970.
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Dmitriev, L.B., Grandberg, I.I. & Moskalenko, V.A. Demjanov reaction with 1-methyl-2-aminomethylpiperidine. Chem Heterocycl Compd 6, 1544–1548 (1970). https://doi.org/10.1007/BF00522578
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DOI: https://doi.org/10.1007/BF00522578