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Asymmetrical alkylation of 1-[(s)-α-phenylethyl]-azethidinone-2

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The methylation of the lithium derivative of azethidinone-2 which has a chiral substituent at the nitrogen atom is asymmetrical and leads, with an optical yield of 35%, to diastereomeric 3-methylated azethidinones-2. The reaction of these compounds with Na in liquid ammonia gives enantiomeric 3-methylazethidinones which confirms that an asymmetrical synthesis has taken place.

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Deceased.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 607–611, May, 1986.

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Romanova, N.N., Budylin, V.A., Grishina, G.V. et al. Asymmetrical alkylation of 1-[(s)-α-phenylethyl]-azethidinone-2. Chem Heterocycl Compd 22, 495–499 (1986). https://doi.org/10.1007/BF00519526

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  • DOI: https://doi.org/10.1007/BF00519526

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