Advertisement

Chemistry of Heterocyclic Compounds

, Volume 19, Issue 8, pp 863–867 | Cite as

Synthesis of 1-aryl-3-(3-pyrrolyl)-5-oxopyrazoles

  • V. P. Zhestkov
  • V. G. Voronin
  • Yu. N. Portnov
Article
  • 28 Downloads

Abstract

1-Aryl-3-(2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolyl)-5-oxopyrazoles were obtained by condensation of ethyl β-(2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolyl)-β-ketopropionate with arylhydrazines. Electron-donor substituants in the aromatic ring of the arylhydrazines accelerate the cyclization of the intermediate hydrazones, whereas electron-acceptor substituents hinder cyclization.

Keywords

Ethyl Organic Chemistry Aromatic Ring Hydrazones Intermediate Hydrazones 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    N. V. Khromov-Borisov, Zh. Obshch. Khim., 25, 136 (1955).Google Scholar
  2. 2.
    G. Coispeau and J. Elguero, Bull. Soc. Chim. Fr., 2717 (1970).Google Scholar
  3. 3.
    L. G. Tensmeier and G. Ainsworth, J. Org. Chem., 31, 1722 (1966).Google Scholar
  4. 4.
    K. Schofield, Hetero-Aromatic Nitrogen Compounds, Pyrrole, and Pyridines, Butterworths, London (1967), p. 89.Google Scholar
  5. 5.
    J. Elguero, G. Guiraud, R. Jacquier, and G. Tarrago, Bull. Soc. Chim. Fr., 5019 (1968).Google Scholar
  6. 6.
    V. P. Zhestkov, V. G. Voronin, M. L. Suslina, and A. S. Zaks, Khim.-farm. Zh., 687 (1982).Google Scholar
  7. 7.
    H. Fischer and H. Orth, Die Chemie des Pyrrols, Vol. 1, Leipzig (1934).Google Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • V. P. Zhestkov
    • 1
  • V. G. Voronin
    • 1
  • Yu. N. Portnov
    • 1
  1. 1.Branch of the S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical ChemistryKupavan

Personalised recommendations