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Synthesis of heterocyclic analogs of prostaglandins from pyrrole and indole

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Heterocyclic analogs of prostaglandin, dl-2-(trans-3-hydroxyocten-lyl)-N-(6-ethoxycarbonylhexyl)pyrrole and -indole were obtained by the condensation of 2-formylpyrrole and 2-formylindole with 2-oxoheptylidenetriphenylphosphorane, followed by alkylation with ethyl 7-iodoheptanoate and reduction of the keto group by sodium borohydride.

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Authors and Affiliations

  1. All-Union Scientific-Research Institute of Technology of Blood Substitutes and Hormonal Preparations, 109044, Moscow

    V. A. Dombrovskii, E. V. Gracheva & P. M. Kochergin

Authors
  1. V. A. Dombrovskii
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  2. E. V. Gracheva
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  3. P. M. Kochergin
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 40–43, January, 1986.

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Dombrovskii, V.A., Gracheva, E.V. & Kochergin, P.M. Synthesis of heterocyclic analogs of prostaglandins from pyrrole and indole. Chem Heterocycl Compd 22, 33–36 (1986). https://doi.org/10.1007/BF00515419

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  • DOI: https://doi.org/10.1007/BF00515419

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