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Synthesis of 3-cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thionks

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

3-Cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thiones have been synthesized for the first time by the condensation of arylideneacetophenones or 1-piperidino-1-phenyl-2-benzoylethane with cyanothioacetamide and the 1, 1-dicyano-2-aryl-3-benzoylpropane with hydrogen sulfide in the presence of bases. It has been established by PMR spectroscopy that 3-cyano-3,4-dihydropyridine-2-thiones exist in solutions in the form of mixture of cis and trans isomers.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    A. A. Krauze, Z. A. Kalme, Yu. É. Pelcher, É. É. Liepin'sh, I. V. Dipan & G. Ya. Dubur

Authors
  1. A. A. Krauze
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  2. Z. A. Kalme
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  3. Yu. É. Pelcher
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  4. É. É. Liepin'sh
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  5. I. V. Dipan
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  6. G. Ya. Dubur
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1515–1520, November, 1983.

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Krauze, A.A., Kalme, Z.A., Pelcher, Y.É. et al. Synthesis of 3-cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thionks. Chem Heterocycl Compd 19, 1202–1207 (1983). https://doi.org/10.1007/BF00515357

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  • DOI: https://doi.org/10.1007/BF00515357

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