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Reaction of 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline with diethyl fumarate

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline with diethyl fumarate goes by two possible paths, to form a mixture of 3-carbethoxymethyl-4-oxo-1,2,3,6, 7,IIb-hexahydro-4H-pyrazino[2,1-a]isoquinoline and its isomer 4-carboxymethyl-3-oxo-1,2,3,6,7-llb-hexahydro-4H-pyrazino[2,1-a]isoquinoline.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 798–800, June, 1985.

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Shekhter, O.V., Sergovskaya, N.L. & Tsizin, Y.S. Reaction of 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline with diethyl fumarate. Chem Heterocycl Compd 21, 665–667 (1985). https://doi.org/10.1007/BF00515068

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  • DOI: https://doi.org/10.1007/BF00515068

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