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Synthesis of 5-hydroxy- and 5-acylhydrazinopyrazolidines by the reaction of β-substituted hydrazides with α,β-unsaturated aldehydes and their biological activity

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of β-substituted hydrazides with alkenals (acrolein, methacrolein, crotonaldehyde, and cinnamaldehyde) serves as a method for the synthesis of the corresponding 1-acyl-5-hydroxypyrazolidines and, in a number of cases, 1-acyl-5-acylhydrazinopyrazolidines. Some of the 1-acyl-5-hydroxypyrazolidines obtained have antiphlogistic activity.

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Authors and Affiliations

  1. S. M. Kirov Military Medical Academy, 194175, Leningrad

    K. N. Zelenin, A. V. Dovgilevich, I. P. Bezhan, G. A. Golubeva, L. A. Sviridova, L. V. Pastushenkov, É. G. Gromova, T. A. Gatchina & S. V. Pomogaibo

  2. M. V. Lomonosov Moscow State University, 117234, Moscow

    K. N. Zelenin, A. V. Dovgilevich, I. P. Bezhan, G. A. Golubeva, L. A. Sviridova, L. V. Pastushenkov, É. G. Gromova, T. A. Gatchina & S. V. Pomogaibo

  3. Leningrad Institute of Pharmaceutical Chemistry, 196022, Leningrad

    K. N. Zelenin, A. V. Dovgilevich, I. P. Bezhan, G. A. Golubeva, L. A. Sviridova, L. V. Pastushenkov, É. G. Gromova, T. A. Gatchina & S. V. Pomogaibo

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  1. K. N. Zelenin
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  2. A. V. Dovgilevich
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  3. I. P. Bezhan
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  4. G. A. Golubeva
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  5. L. A. Sviridova
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  6. L. V. Pastushenkov
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  7. É. G. Gromova
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  8. T. A. Gatchina
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  9. S. V. Pomogaibo
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 659–666, May, 1984.

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Zelenin, K.N., Dovgilevich, A.V., Bezhan, I.P. et al. Synthesis of 5-hydroxy- and 5-acylhydrazinopyrazolidines by the reaction of β-substituted hydrazides with α,β-unsaturated aldehydes and their biological activity. Chem Heterocycl Compd 20, 529–536 (1984). https://doi.org/10.1007/BF00514307

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  • DOI: https://doi.org/10.1007/BF00514307

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