Chemistry of Heterocyclic Compounds

, Volume 20, Issue 4, pp 422–425 | Cite as

Fluorine-containing azoles. 2. Reaction of imidazole, benzimidazoles, and perimidines with difluorocarbene

  • V. G. Poludnenko
  • O. B. Didinskaya
  • A. F. Pozharskii


The reaction of difluorocarbene, generated from difluorochloromethane in an alkaline medium or from sodium trifluoroacetate in a neutral medium, with imidazole, tetrahydrobenzimidazole, benzimidazoles, and perimidines leads to the production of their N-difluoromethyl-substituted derivatives.


Sodium Organic Chemistry Imidazole Benzimidazole Azole 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • V. G. Poludnenko
    • 1
  • O. B. Didinskaya
    • 1
  • A. F. Pozharskii
    • 1
  1. 1.State Scientific-Research and Planning Institute of the Chlorine IndustryBorislav

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