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Investigation of the barriers to retarded internal rotation in N-acyl-1-methyl-1,2,3,4-tetrahydroisoquinolines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The effect of a number of alkyl substituents attached to the carbon atom of the acyl group on the activation parameters of retarded internal rotation about the C-N bond in N-acyl-1-methyl-1,2,3,4-tetrahydroisoquinolines was studied. Correlation of the free energies of activation ΔG ≠298 with the steric factors (Es) and the σ* substituent constants was examined.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, 117234, Moscow

    S. N. Dvoryantsev, V. I. Mstislavskii & V. M. Dem'yanovich

Authors
  1. S. N. Dvoryantsev
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  2. V. I. Mstislavskii
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  3. V. M. Dem'yanovich
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 502–505, April, 1984.

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Dvoryantsev, S.N., Mstislavskii, V.I. & Dem'yanovich, V.M. Investigation of the barriers to retarded internal rotation in N-acyl-1-methyl-1,2,3,4-tetrahydroisoquinolines. Chem Heterocycl Compd 20, 405–408 (1984). https://doi.org/10.1007/BF00513856

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  • DOI: https://doi.org/10.1007/BF00513856

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