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Silyl methods for the modification of penicillin and cephalosporin (review)

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The principal pathways of modification of β-lactam antibiotics by means of silyl methods, including silylation, the preparation of N-acyl and amide analogs of penicillin and cephalosporin, the deacylation of N-protective groups, the epimerization of the side chain, the transformation of penicillin to cephalosporin, and other transformations, are examined.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    G. A. Veinberg, L. N. Petrulyanis & É. Ya. Lukevits

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  1. G. A. Veinberg
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  2. L. N. Petrulyanis
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  3. É. Ya. Lukevits
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 147–162, February, 1982.

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Veinberg, G.A., Petrulyanis, L.N. & Lukevits, É.Y. Silyl methods for the modification of penicillin and cephalosporin (review). Chem Heterocycl Compd 18, 111–123 (1982). https://doi.org/10.1007/BF00512950

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  • DOI: https://doi.org/10.1007/BF00512950

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