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Acetals of lactams and acid amides

XXVII. New synthesis of pyrido[2,3-d]pyrimidine derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

7-Dimethylamino-5-hydroxypyrido[2,3-d]pyrimidine and pyrrolo-, pyrido, and azepino [2,3-b]pyrido[2,3-d]pyrimidine derivatives were synthesized by reaction of acetals of amides and lactams with 4-amino-5-carbethoxypyrimidine derivatives and subsequent intramolecular cyclization of the intermediate amidines. The reactions of these compounds with phosphorus oxychloride and their alkylation reactions were studied.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, 119021, Moscow

    V. G. Granik, N. B. Marchenko & R. G. Glushkov

Authors
  1. V. G. Granik
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  2. N. B. Marchenko
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  3. R. G. Glushkov
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Additional information

See [1] for communication XXVI.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1549–1554, November, 1978.

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Granik, V.G., Marchenko, N.B. & Glushkov, R.G. Acetals of lactams and acid amides. Chem Heterocycl Compd 14, 1261–1266 (1978). https://doi.org/10.1007/BF00509750

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  • DOI: https://doi.org/10.1007/BF00509750

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