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Substitution reactions involving the 2,6-methyl groups of 1,4-dihydropyridines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

4,4-Disubstituted 1,4-dihydropyridines (I) are brominated with bromine in chloroform to give 2,6-bis(bromomethyl)-4,4-disubstituted 1,4-dihydropyridines (II), whereas 2,6-bis(dibromomethyl)-4,4-disubstituted 1,4-dihydropyridines (III) are obtained in the case of bromination of I in acetic acid. The bromine atoms in II and III are labile and readily undergo nucleophilic substitution.

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Literature cited

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    V. V. Kastron, A. M. Kats, G. Ya. Dubar & R. M. Zolotoyabko

Authors
  1. V. V. Kastron
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  2. A. M. Kats
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  3. G. Ya. Dubar
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  4. R. M. Zolotoyabko
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1519–1524, November, 1978.

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Kastron, V.V., Kats, A.M., Dubar, G.Y. et al. Substitution reactions involving the 2,6-methyl groups of 1,4-dihydropyridines. Chem Heterocycl Compd 14, 1236–1240 (1978). https://doi.org/10.1007/BF00509744

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  • DOI: https://doi.org/10.1007/BF00509744

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