Chemistry of Heterocyclic Compounds

, Volume 14, Issue 11, pp 1236–1240 | Cite as

Substitution reactions involving the 2,6-methyl groups of 1,4-dihydropyridines

  • V. V. Kastron
  • A. M. Kats
  • G. Ya. Dubar
  • R. M. Zolotoyabko


4,4-Disubstituted 1,4-dihydropyridines (I) are brominated with bromine in chloroform to give 2,6-bis(bromomethyl)-4,4-disubstituted 1,4-dihydropyridines (II), whereas 2,6-bis(dibromomethyl)-4,4-disubstituted 1,4-dihydropyridines (III) are obtained in the case of bromination of I in acetic acid. The bromine atoms in II and III are labile and readily undergo nucleophilic substitution.


Acetic Acetic Acid Organic Chemistry Chloroform Bromine 
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Literature cited

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • V. V. Kastron
    • 1
  • A. M. Kats
    • 1
  • G. Ya. Dubar
    • 1
  • R. M. Zolotoyabko
    • 1
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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