Research on lactams
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The reaction of O-phenylhydroxylamine hydrochloride with α-oxocaprolactam gave α-oxocaprolactam O-phenyloxime, which gave two substances -1,2,3,4-tetrahydro-pyrido[2,3-c]coumarin as the principal product and 1-oxo-10a-hydroxy-1H-2,3,4,5, 5a,10a-hexahydrobenzofuro[2,3-c]azepine as the minor product — under the conditions of the Fischer reaction. The minor product was converted to 1-oxo-1H-2,3, 4,5-tetrahydrobenzofuro[2,3-c]azepine in quantitative yield by dehydration in trifluoroacetic acid.
KeywordsOrganic Chemistry Dehydration Hydrochloride Coumarin Trifluoroacetic Acid
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