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Chemistry of Heterocyclic Compounds

, Volume 14, Issue 11, pp 1196–1198 | Cite as

Reactions of aromatic and heteroaromatic compounds containing electron-acceptor substituents

XXIII. New method for the chloromethylation of carbonyl compounds of the thiophene and benzene series
  • Ya. L. Gol'dfarb
  • I. B. Karmanova
  • Yu. B. Vol'kenshtein
  • L. I. Belen'kii
Article

Abstract

A method was developed for the preparation of 4-chloromethyl-2-acylthiophenes and m-(chloromethyl)acylbenzenes in up to 65% yields by the action of paraformaldehyde and anhydrous aluminum chloride on the corresponding carbonyl compounds. The reaction mechanism is discussed.

Keywords

Aluminum Chloride Organic Chemistry Carbonyl Paraformaldehyde 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Ya. L. Gol'dfarb
    • 1
  • I. B. Karmanova
    • 1
  • Yu. B. Vol'kenshtein
    • 1
  • L. I. Belen'kii
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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