Abstract
When 7-aroylalkyl-8-bromo-3-methyl- and 1,3-dimethylxanthines are boiled with an excess of thioglycolic acid, a reductive dehalogenation takes place, while reaction with an equimolar amount of thioglycolic acid in DMFA leads to 7-aroylalkyl-3-methyl- and 1,3-dimethylxanthinyl-8-thioacetic acids. Cyclization of the latter with acetic anhydride in the presence of anhydrous sodium acetate results in the formation of 3-aryl-1,4-dihydro-9-methyl- and-7,9-dimethylthiazino[3,2-f]xanthine.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 967–970, July, 1990.
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Garmash, S.N., Skul'skaya, E.A., Priimenko, B.A. et al. Synthesis and properties of derivatives of 7-aroylalkylxanthinyl-8-thioacetic acid. Chem Heterocycl Compd 26, 807–811 (1990). https://doi.org/10.1007/BF00509713
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DOI: https://doi.org/10.1007/BF00509713