Abstract
1-(α-Alkoxyethyl)- and 1-(α-phenoxyethyl)benzimidazole-2-thiones were obtained in the reaction of 1-vinylbenzimidazole-2-thione with alcohols and phenol in the presence of gaseous hydrogen chloride. It was established that partial hydrolysis of the 1-(α-alkoxyethyl)benzimidazole-2-thiones to benzimidazole-2-thione with subsequent alkylation with excess alcohol at the exocyclic sulfur atom occurs under the conditions of the investigated reaction. A convenient method for the alkylation of thiones was proposed, and a number of 2-alkylthiobenzimidazoles were synthesized.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
N. D. Abramova, G. G. Skvortsova, B. V. Trzhtsinskaya, and M. V. Sigalov, Khim. Geterotsikl. Soedin., No. 12, 1674 (1975).
M. L. Martin, F. Lefevre, D. Lapeyre, and G. Martin, J. Org. Magn. Reson., 1, 19 (1969).
G. G. Skvortsova, E. S. Domnina, N. P. Glaskova, N. N. Chipanina, and N. I. Shergina, Zh. Obshch. Khim., 41., 623 (1971).
K. Futaki, J. Pharm. Soc. Japan, 74, 1365 (1954); Chem. Abstr., 49, 15876 (1955).
Author information
Authors and Affiliations
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 805–807, June, 1984.
Rights and permissions
About this article
Cite this article
Abramova, N.D., Skvortsova, G.G. & Trzhtsinskaya, B.V. Reactions of 1-vinylbenzimidazole-2-thione with alcohols and phenol. Chem Heterocycl Compd 20, 656–658 (1984). https://doi.org/10.1007/BF00508677
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00508677