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Investigation of naphthyridines. 12. Synthesis of substituted 5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridines by cyclization of 2-styrylnicotinic acid amides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Substituted amides of 2-styrylnicotinic acid were obtained by condensation of 2-methylnicotinic acid arylamides with benzaldehyde, and it was found that they undergo cyclization to 5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridine derivatives when they are heated in polyphosphoric acid.

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Literature cited

  1. N. I. Shramm and M. E. Konshin, Khim. Geterotsikl. Soedin., No. 3, 372 (1983).

    Google Scholar 

  2. T. Takahasi, Y. Hamada, Y. Takeuti, and H. Itiyama, J. Pharm. Soc. Jpn., 89, 1260 (1969); Ref. Zh. Khim., 10Zh398 (1970).

    Google Scholar 

  3. G. Lesher, US Patent No. 3225055; Ref. Zh. Khim., 18N286P (1967).

  4. P. Strehlke and H. Kessler, West German Patent No. 2656574; Ref. Zh. Khim., 7021611 (1979).

  5. J. M. Bobbitt and R. E. Doolittle, J. Org. Chem., 29, 2298 (1964).

    Google Scholar 

  6. A. K. Sheinkman, A. N. Rozenberg, and L. S. Emel'yanova, in: Methods for the Synthesis of Chemical Reagents and Preparations [in Russian], Vol. 13, Izd. IREA (1965), p. 102.

    Google Scholar 

  7. V. I. Sigova, N. V. Semyakina, V. S. Zalesov, and M. E. Konshin, Khim.-farm. Zh. (1983, in press).

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Authors and Affiliations

  1. Perm State Pharmaceutical Institute, 614600, Perm

    V. I. Sigova & M. E. Konshin

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  1. V. I. Sigova
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  2. M. E. Konshin
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Additional information

See [1] for communication 11.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 783–785, June, 1984.

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Sigova, V.I., Konshin, M.E. Investigation of naphthyridines. 12. Synthesis of substituted 5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridines by cyclization of 2-styrylnicotinic acid amides. Chem Heterocycl Compd 20, 635–636 (1984). https://doi.org/10.1007/BF00508672

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  • DOI: https://doi.org/10.1007/BF00508672

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