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Acetals of lactams and acid amides. 36. Some reactions of enamines of the isoquinoline series and synthesis of pyrimido[4,3-a]isoquinolines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reactions of 1-methylene-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives with acyl chlorides were investigated. 2-Oxopyrimido[4,3-a]isoquinoline derivatives were obtained by the reaction of 1-carbamidomethylene-6,7-dimethoxy-1,2, 3,4-tetrahydroisoquinoline with dimethylformamide and dimethylacetamide diethylacetals. The reaction of the latter with phosphorus oxychloride and then with primary amines was used to synthesize a number of hydrochlorides that are derivatives of 2-iminopyrimido[4,3-a]isoquinoline.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow

    V. G. Granik, V. F. Knyazeva, I. V. Persianova, N. P. Solov'eva & R. G. Glushkov

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  1. V. G. Granik
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  2. V. F. Knyazeva
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  3. I. V. Persianova
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  4. N. P. Solov'eva
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  5. R. G. Glushkov
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Additional information

See [1] for Communication 35.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1095–1099, August, 1982.

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Granik, V.G., Knyazeva, V.F., Persianova, I.V. et al. Acetals of lactams and acid amides. 36. Some reactions of enamines of the isoquinoline series and synthesis of pyrimido[4,3-a]isoquinolines. Chem Heterocycl Compd 18, 838–842 (1982). https://doi.org/10.1007/BF00506592

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  • DOI: https://doi.org/10.1007/BF00506592

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