Abstract
5,6-Dihydro-8-methyl-4H-pyrazino[3,2,1-j,k]carbazole was obtained by the reaction of α-bromoacetaldehyde dibutylacetal, ammonium acetate, and 1,2,3,4-tetrahydro-6-methyl-1-ketocarbazole in acetic acid. The reduction of 5,6-dihydro-8-methyl-4H-pyrazino[3,2,1-j,k]carbazole or its hydrochloride with sodium borohydride leads to 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole hydrochloride — the medicinal preparation pirazidol.
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V. I. Shvedov, E. S. Krichevskii, O. B. Romanova, A. N. Grinev, N. I. Andreeva, and M. D. Mashkovskii, Khim.-farm. Zh., No. 5, 85 (1978).
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V. I. Shvedov, L. B. Altukhova, N. I. Andreeva, M. D. Mashkovskii, and A. N. Grinev, Khim.-farm. Zh., No. 10, 14 (1972).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1362–1363, October, 1983.
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Grinev, A.N., Krichevskii, É.S. & Romanova, O.B. New simple laboratory method for the synthesis of pirazidol. Chem Heterocycl Compd 19, 1084–1085 (1983). https://doi.org/10.1007/BF00505759
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DOI: https://doi.org/10.1007/BF00505759