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Reaction of indoles with trifluoroacetic acid

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

3-Trifluoroacetyl indoles are formed by the action of trifluoroacetic acid on indole-2-carboxylic acid and its benzo-substituted derivatives. When unsubstituted indole is refluxed with trifluoroacetic acid, it gives 3-trifluoroacetylindole in 30% yield.

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Literature cited

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, 117234, Moscow

    A. N. Kost, V. A. Budylin, N. N. Romanova & E. D. Matveeva

Authors
  1. A. N. Kost
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  2. V. A. Budylin
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  3. N. N. Romanova
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  4. E. D. Matveeva
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Additional information

Deceased.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1233–1235, September, 1981.

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Kost, A.N., Budylin, V.A., Romanova, N.N. et al. Reaction of indoles with trifluoroacetic acid. Chem Heterocycl Compd 17, 921–923 (1981). https://doi.org/10.1007/BF00505598

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  • DOI: https://doi.org/10.1007/BF00505598

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