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Beckmann rearrangement of acetylthiophene oxime benzenesulfonates as a method for the synthesis of acetamidothiophenes

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The Beckmann rearrangement of 2-acetylthiophene, 5-methyl-2-acetylthiophene, 5-chloro-2-acetylthiophene, and 2,5-dichloro-3-acetylthiophene oxime benzenesulfonates to the corresponding acetamidothiophenes was carried out by heating with an aqueous methanol solution of sodium acetate. This method can be used for the preparative synthesis of 2-acetamidothiophene and 2,5-dichloro-3-acetamido-thiophene.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, 117913, Moscow

    B. P. Fabrichnyi, V. N. Bulgakova & Ya. L. Gol'dfarb

Authors
  1. B. P. Fabrichnyi
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  2. V. N. Bulgakova
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  3. Ya. L. Gol'dfarb
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 483–485, April, 1985.

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Fabrichnyi, B.P., Bulgakova, V.N. & Gol'dfarb, Y.L. Beckmann rearrangement of acetylthiophene oxime benzenesulfonates as a method for the synthesis of acetamidothiophenes. Chem Heterocycl Compd 21, 401–403 (1985). https://doi.org/10.1007/BF00504398

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  • DOI: https://doi.org/10.1007/BF00504398

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