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Chemistry of Heterocyclic Compounds

, Volume 16, Issue 11, pp 1176–1179 | Cite as

Analogs of pyrimidine nucleosides. 14. Synthesis and antitumorigenic activity of alkoxyalkyl derivatives of 5-fluorouracil

  • M. Ya. Karpeiskii
  • S. M. Mikhailov
  • A. S. Tsieminya
  • A. A. Ziderman
  • I. M. Kravchenko
  • M. Yu. Lidak
  • R. A. Zhuk
Article

Abstract

A number of alkoxyalkyl derivatives of 5-fluorouracil were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with α-chloro ethers or by the addition of 5-fluorouracil to vinyl ethers. It was established that the synthesized compounds are capable of increasing the lifetimes of mice with L-1210 leukemia and La hemocytoblastosis. The UV and NMR spectra of the synthesized compounds are presented.

Keywords

Ether Leukemia Organic Chemistry Vinyl Pyrimidine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

  1. 1.
    S. A. Giller, R. A. Zhuk, and M. Yu. Lidak, Dokl. Akad. Nauk SSSR, 176. 332 (1967).Google Scholar
  2. 2.
    N. G. Blokhina, A. M. Garin, E. K. Voznyi, A. M. Lipatov, N. I. Karev, and N. V. Burachevskaya, in: Experimental and Clinical Pharmacotherapy [in Russian], Vol. 7, Zinatne, Riga (1977), p. 224.Google Scholar
  3. 3.
    O. S. Stepanova, O. I. Tishchenko, A. I. Drozdovskaya, É. A. Kal'nitskaya, T. D. Pantsuk, and E. A. Yatsenko, Zh. Vsesoyuzn. Khim. Obshchestva, No. 5, 598 (1963).Google Scholar
  4. 4.
    M. F. Shostakovskii, Vinyl Ethers [in Russian], Moscow (1952), p. 108.Google Scholar
  5. 5.
    L. Yu. Tychinskaya and V. L. Florent'ev, Bioorg. Khim., 4, 1461 (1978).Google Scholar
  6. 6.
    H. J. Schaffer, L. Beauchamp, P. de Miranda, G. B. Elien, D. J. Bauer, and P. Collins, Nature, 272. 583 (1978).Google Scholar
  7. 7.
    R. A. Zhuk, M. Yu. Lidak, A. P. Gilev, A. A. Ziderman, A. S. Tsieminya, and A. N. Kozhukhov, Current Problems in the Experimental Chemotherapy of Tumors [in Russian], Part 1, Chernogolovka (1980), p. 40.Google Scholar
  8. 8.
    Yu. V. Pokonova, Halo Ethers [in Russian], Khimiya, Moscow-Leningrad (1966), p. 281.Google Scholar
  9. 9.
    L. T. Kaulinya, M. Yu. Lidak, and R. A. Zhuk, Khim. Geterotsikl. Soedin., No. 8, 1109 (1980).Google Scholar

Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • M. Ya. Karpeiskii
    • 1
    • 2
  • S. M. Mikhailov
    • 1
    • 2
  • A. S. Tsieminya
    • 1
    • 2
  • A. A. Ziderman
    • 1
    • 2
  • I. M. Kravchenko
    • 1
    • 2
  • M. Yu. Lidak
    • 1
    • 2
  • R. A. Zhuk
    • 1
    • 2
  1. 1.Institute of Molecular BiologyAcademy of Sciences of the USSRMoscow
  2. 2.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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