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Investigation of the reaction of 2-aminotheophyllines with glycerol epichlorohydrin

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Depending on the nature and amount of the base used, as well as the reaction time, the following compounds are formed in the reaction of 8-aminothiophyl-lines with glycerol epichlorohydrin in anhydrous propanol; 7-(2-hydroxy-3-chloro-1-propyl)-8-arylaminotheophylline, 1,3-bis(8-arylamino-7-theophyllinyl)-2-hydroxypropane, 7-(2,3-epoxy-1-propy1)-8-alkyl(aryl) aminothiophyllines or 9-alkyl(aryl)-7-hydroxy-1,3-dimethyl-6,7,8,9-tetrahydropyrimido [2,1-f]purine-2,4-(1H,3H)diones. The structures of the compounds were confirmed by alternative synthesis and by data from the IR spectra. The mass spectrum of one of the compounds is presented.

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Authors and Affiliations

  1. Zaporozhe Medical Institute, 330074, Zaporozhe

    A. A. Kremzer, Yu. V. Strokin, N. A. Klyuev & V. P. Buryak

Authors
  1. A. A. Kremzer
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  2. Yu. V. Strokin
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  3. N. A. Klyuev
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  4. V. P. Buryak
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1102–1105, August, 1981.

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Kremzer, A.A., Strokin, Y.V., Klyuev, N.A. et al. Investigation of the reaction of 2-aminotheophyllines with glycerol epichlorohydrin. Chem Heterocycl Compd 17, 821–824 (1981). https://doi.org/10.1007/BF00503667

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  • DOI: https://doi.org/10.1007/BF00503667

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